Human Genetics: Concepts and Applications (Lewis), 9th Edition

Chapter 10: Gene Action: From DNA to Protein

How Prions Arise

View the animation below, then complete the quiz to test your knowledge of the concept.



1.

Which of the following diseases is(are) caused by prions?
A)mad cow disease
B)Creutzfeldt-Jacob disease in humans
C)scrapie disease in sheep
D)A and B
E)A, B, and C
2.

The normal prion protein is
A)bound to the ribosomes of neurons.
B)bound to the cell membrane of neurons.
C)found in the nucleus of neurons.
D)found in the mitochondria of neurons.
E)found in the synapse between neurons.
3.

A harmless PrP is converted into the infective PrP
A)only as a result of a mutation in the normal gene.
B)by a virus which binds to the normal protein and causes it to become misfolded.
C)by an abnormal PrP which binds to the normal protein and causes it to become misfolded.
D)by enzymes that break off parts of the harmless protein.
E)by interaction of a PrP from one species with that of a second species.
4.

The gene for the prion protein has been found in vertebrates but not invertebrates.
A)True
B)False
5.

The abnormal form of the protein is called PrPSc.
A)True
B)False
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