Human Genetics: Concepts and Applications (Lewis), 9th Edition

Chapter 20: Genetic Testing and Treatment

Practice Tests

1
Why can single-gene disorders be difficult for physicians to diagnose?
A)They do not have a specific cause.
B)They can produce a variety of symptoms that appear to be unrelated.
C)They are usually fatal.
D)They usually do not cause a noticeable phenotype.
2
True or False. Currently, genetic counselors are required to be nondirective in their approach with patients.
A)True
B)False
3
What type of genetic screening tests would focus on the breast and ovarian cancer genes BRCA1 and BRCA2?
A)prenatal
B)carrier screening
C)predisposition
D)newborn
4
A man and woman, each with a family history of sickle cell disease and no children would benefit most by _____.
A)prenatal screening
B)carrier screening
C)predisposition testing
D)having no screening because they already know their status
5
Which of the following tests provide population-wide testing for inborn errors of metabolism?
A)prenatal
B)carrier screening
C)predisposition
D)newborn
6
True or False. Genetic testing is only effective on newborns.
A)True
B)False
7
A genetic counselor's job may include _____.
A)explaining Mendel's laws
B)recommending testing of relatives
C)reviewing a family's health history
D)All of the above
8
True or False. Genetic counselors communicate with patients but not with physicians or other health care professionals.
A)True
B)False
9
A lack of T cells, as seen in ADA deficiency, can _____.
A)cause an overproduction of certain antibodies
B)lead to severe combined immune deficiency (SCID)
C)inhibit blood clotting
D)cause acquired immune deficiency syndrome (AIDS)
10
Germline gene therapy is _____.
A)heritable
B)not heritable
C)sometimes heritable
D)unrelated to heritability
11
The first gene therapy used cells altered outside the recipient's body and is called ____ gene therapy.
A)in situ
B)in vivo
C)ex vivo
D)vaccine
12
Which of the following is not a vector used in gene therapy?
A)adeno-associated virus (AAV)
B)adenovirus (AV)
C)retrovirus
D)HIV
13
A transgenic mouse is an example of _____.
A)germline gene therapy
B)noninheritable gene therapy
C)constitutional gene therapy
D)somatic gene therapy
14
Germline gene therapy could potentially correct a genetic defect in a(n)_____.
A)affected individual only
B)affected individual and his or her offspring only
C)affected individual and all of his or her descendants
D)parent of an affected child
15
A mechanism of gene therapy involving the alteration of muscle cells could be used to treat _____.
A)cystic fibrosis
B)muscular dystrophy
C)ataxia
D)Tay-Sachs disease
16
Gene therapy is unlike conventional drug therapy in that it attempts to alter an individual's ____ in a part of the body that has malfunctioned.
A)genotype only
B)phenotype only
C)Either a or b depending on the application
17
Why are neurons difficult targets for gene therapy?
A)they are not easily accessible
B)they are small
C)they do not divide
D)they lack a nucleus
18
About half of current gene therapy trials target _____.
A)cystic fibrosis
B)cancer
C)ADA deficiency
D)sickle cell disease
19
Melanoma is amenable to _____.
A)in vivo gene therapy
B)ex vivo gene therapy
C)in situ gene therapy
20
A nasal spray containing adenovirus carrying a functional human CFTR gene is used to treat cystic fibrosis. This is an example of ____ gene therapy.
A)germline
B)somatic
C)transgenic
D)vaccine
21
Gene therapy would have to correct ____ of the cells in the liver to be effective.
A)1%
B)5%
C)10%
D)50%
22
____ deficiency was the first disorder researchers treated with gene therapy.
A)ADA
B)OTC
C)HH
D)DMD
23
Jesse Gelsinger died during a gene therapy experiment aimed at treating his ____ deficiency.
A)ADA
B)OTC
C)Canavan
D)DMD
24
The disease that disrupts interactions between neurons and oligodendrocytes is called _____.
A)ADA
B)OTC
C)Canavan disease
D)DMD
25
Which vector used in gene therapy has proved useful in the treatment of sickle cell disease?
A)adeno-associated virus
B)adenovirus
C)retrovirus
26
Genetic counselors provide information on _____.
A)inheritance patterns
B)disease risks and symptoms
C)available tests and treatments
D)All of the above
27
True or False. Somatic gene therapy affects tissue that is passed on to offspring.
A)True
B)False
28
Requirements for approval of clinical trials for gene therapy include _____.
A)knowledge of defect and how it causes symptoms
B)an animal model
C)success in human cells growing in vitro
D)no alternate therapies, or patients for whom existing therapies are not possible or have not worked
E)safe experiments
F)All of the above
29
A ____ confirms a diagnosis based on symptoms.
A)carrier screen
B)prenatal test
C)prenatal screen
D)diagnostic test
30
Genetically altered ____ can secrete a needed protein directly into the bloodstream.
A)brain tissue
B)skin
C)endothelium
D)neurons
Glencoe Online Learning CenterScience HomeProduct InfoSite MapContact Us

The McGraw-Hill CompaniesGlencoe

Please read our Terms of Use and Privacy Notice before you explore our Web site. To report a technical problem with this Web site, please contact the Web Producer.