Human Genetics, 10th Edition, (Lewis)What's NewNew and updated information is integrated throughout the chapters. Highlights from the revision are included here. Chapter 1 Overview of Genetics■ A university encourages genetic testing of incoming freshmen—until stopped. Chapter 2 Cells ■ A “disease-in-a-dish” for a rare condition opens the chapter. Chapter 3 Meiosis and Development ■ Can sirtuins slow aging? Chapter 4 Single-Gene Inheritance ■ Family genome analysis bridges Mendelian and molecular genetics. Chapter 5 Beyond Mendel’s Laws ■ Genetic heterogeneity is seen through the eyes of families at a conference for hereditary blindness. Chapter 6 Matters of Sex ■ Wiskott-Aldrich syndrome opens the chapter. ■ Hemophilia B affected the royal families, not hemophilia A. Chapter 7 Multifactorial Traits ■ “Genetics of Athletics” opens the chapter. ■ More emphasis on epigenetics. Faces: a compelling example of normal variation revealed with genome-wide association studies. Chapter 8 Genetics of Behavior ■ Behavioral disorders may not be distinct at the genetic level. ■ How are autism and schizophrenia related? Chapter 10 Gene Action: From DNA to Protein ■ “Whole exome sequencing” opens the chapter. Chapter 11 Gene Expression and Epigenetics ■ How famine sowed the seeds of schizophrenia, thanks to epigenetics. Chapter 12 Gene Mutation ■ Restoring protein folding to treat cystic fibrosis opens the chapter. ■ Allelic diseases explain old mysteries. Chapter 14 Constant Allele Frequencies ■ Forensics update: touch DNA, familial DNA searches, fish fraud. Chapter 15 Changing Allele Frequencies ■ Update on dog and cat genetics. ■ “Mutiny on the Bounty” and migraine: a profound founder effect. Chapter 16 Human Ancestry ■ Exploiting the Havasupai in Bioethics: Choices for the Future. ■ Neanderthal genome reveals we interbred. ■ Denisova hominins shared Europe with our ancestors and Neanderthals. ■ DNA of the Khoisan is the most diverse. ■ A newly discovered paleo-Eskimo from Greenland reveals an ancient migration route. Chapter 17 Genetics of Immunity ■ The Berlin patient: curing leukemia and HIV. ■ A new view of allergy, due to mutation. Chapter 19 Genetic Technologies: Amplifying, Modifying, and Monitoring DNA ■ Experimental evolution and the Gulf oil spill. Chapter 20 Genetic Testing and Treatment ■ Max Randell turns 13, thanks to gene therapy for Canavan disease. ■ Preconception comprehensive carrier testing for 400+ diseases. ■ Cell-free fetal DNA reveals entire fetal genomes. ■ Repurposed drugs treat common genetic diseases. ■ Gene therapy returns with three successes. Chapter 21 Reproductive Technologies ■ “The Twiblings” open the chapter. ■ The ethics of postmortem gamete retrieval, male and female. Chapter 22 Genomics ■ Updates on genome projects. ■ Sequencing the Cacao genome (chocolate). ■ The human microbiome. ■ How useful is a personal genome sequence? |  |
