Human Genetics, 10th Edition, (Lewis)

Chapter 12: Gene Mutation

Learning Outcomes


12.1

 

The Nature of Mutations

1.

  

Distinguish between mutation and mutant.

2.

  

Distinguish between mutation and polymorphism.

12.2

 

Two Mutations

3.

  

Describe mutations in the beta globin gene and in collagen.

12.3

 

Causes of Mutation

4.

  

Explain the chemical basis of a spontaneous mutation.

5.

  

Describe other ways that mutations occur.

12.4

 

Types of Mutations

6.

  

Describe the two types of single-base mutations.

7.

  

Explain the consequences of a splice-site mutation.

8.

  

Discuss mutations that add, remove, and move DNA nucleotides.

12.5

 

The Importance of Position

9.

  

Give examples of how the location of a mutation in a gene affects the phenotype.

10.

  

Describe a conditional mutation.

12.6

 

DNA Repair

11.

  

What types of damage do DNA repair mechanisms counter?

12.

  

Describe the types of DNA repair.

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