Human Genetics, 10th Edition, (Lewis)

Chapter 22: Genomics

Practice Tests

1
Which answer lists the genetic maps from the most detailed to the least detailed?
A)physical -- sequence -- cytogenetics -- linkage
B)sequence -- linkage -- physical -- cytogenetic
C)physical -- sequence -- linkage -- cytogenetic
D)sequence -- physical -- linkage -- cytogenetic
2
The approach that matches single genes to specific diseases is called _____.
A)comparative genomics
B)proteomics
C)positional cloning
D)organismal cloning
3
The Human Genome Project officially began in _____ under the direction of _____.
A)1988; Francis Crick
B)1990; James Watson
C)1992; J. Craig Venter
D)1995; Francis Collins
4
Funding for the Human Genome Project comes from _____.
A)the National Institutes of Health
B)the Department of Energy
C)the National Institutes of Health and the Department of Energy
D)the National Institutes of Health, the Department of Energy, and ELSI
5
Genome projects are limited to the study of humans.
A)True
B)False
6
The first organism to have its complete genome sequenced was _____.
A)Haemophilus influenzae
B)Escherichia coli
C)Mycoplasma genitalium
D)Saccharomyces cerevisiae
7
The first organism to have its complete genome synthesized in a laboratory was _____.
A)Haemophilus influenzae
B)Escherichia coli
C)Mycoplasma genitalium
D)Saccharomyces cerevisiae
8
The "first draft" of the human genome sequence was unveiled in _____.
A)1991
B)1995
C)2000
D)2004
9
Expressed sequence tags (ESTs) are derived from _____.
A)cDNA
B)rRNA
C)proteins
D)Any of the above
10
BACs are _____.
A)a bacterial artificial chromosome
B)a form of cDNA
C)a type of DNA sequencing reaction
D)None of the above
11
The genome of this organism is generally considered to define the minimum gene set required for life.
A)Methanococcus janaschii
B)Mycoplasma genitalium
C)Saccharomyces cerevisiae
D)Escherichia coli
12
True or False. Even though the fruit fly Drosophila melanogaster is more complex than the nematode worm Caenorhabditis elegans, the genome of C. elegans revealed that it contained more genes.
A)True
B)False
C)This has not been determined.
13
About ____ of the genes in Saccharomyces cerevisiae have counterparts among mammals.
A)1/4
B)1/3
C)1/2
D)2/3
14
The field of ____ uses conserved sequences to identify biologically important genome regions.
A)positional cloning
B)Sanger method
C)comparative genomics
D)gene expression
15
Two general approaches were used to derive the sequence of the human genome. The ____________ technique was used by the U.S. government-funded group and aligned DNA pieces one chromosome at a time.
A)whole genome shotgun
B)clone-by-clone
C)Sanger
D)microarray
16
Comparative genomics has revealed that about ____ of the human genome sequence is highly conserved.
A)1%
B)6%
C)98%
D)33%
17
Who was the first person to have his or her genome sequence published?
A)Craig Venter
B)James Watson
C)George Church
D)T. H. Roderick
18
The collection of all of the genomes from the microorganisms in and on our bodies is called the _____________.
A)biobank
B)methylome
C)diseasome
D)human microbiome
19
Research indicates that each of us has ___________ mutations that would affect health if present in two copies.
A)250 to 300
B)about 6,000
C)50 to 100
D)20 to 200 million
20
New types of maps being constructed by researchers focus on which of these?
A)patterns of gene expression
B)distributions of SNPs
C)distributions of methylation sites
D)networks of gene interactions
E)all of these
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